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- September 2, 2010 |
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"Lung function and inhaled insulin in diabetes"Prof. Timothy Davis (biography)
English - 2009-07-24 - 36 minutes
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Summary :
Pulmonary involvement in diabetes was first reported about thirty years ago, and in 1989 a cross-sectional study from Denmark was published showing slightly impaired lung function among diabetic patients, which was more apparent in those taking insulin (1).
More recently, cross-sectional and prospective data from the Fremantle Diabetes Study shed further light on the topic. In this cohort of type 2 diabetic patients, it was found that pulmonary function is reduced in type 2 diabetes, and diabetes duration seemed a more important influence than glycaemic control, but obesity and vascular disease may also contribute (2). The subsequent longitudinal study concluded that “reduced lung volumes and airflow limitation are likely to be chronic complications of type 2 diabetes, the severity of which relates to glycemic exposure” (3).
Pulmonary delivery of insulin has been the focus of research since the time insulin was discovered in the 1920s. Recent advances in the development of devices and formulations have allowed inhaled insulin to become a viable treatment option. Prof. Davis describes the problems with inhaled insulin, its pharmacodynamic properties, role in blood glucose control, and why its future is yet uncertain.
Copyright © 2009 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The effect of diabetes on the lung
- The rationale for inhaled insulin
- The status of inhaled insulin
Bibliographic references :
1. Lange P, Groth S, Kastrup J, Mortensen J, Appleyard M, Nyboe J, Jensen G, Schnohr P. Diabetes mellitus, plasma glucose and lung function in a cross-sectional population study. Eur Respir J. 1989 Jan;2(1):14-9.
2. Timothy M.E Davis, Matthew Knuiman, Peter Kendall, Hien Vu, Wendy A Davis Reduced pulmonary function and its associations in type 2 diabetes: the Fremantle Diabetes Study Diabetes Research and Clinical Practice - 1 October 2000 (Vol. 50, Issue 2, Pages 153-159)
3. Davis WA, Knuiman M, Kendall P, Grange V, Davis TM; Fremantle Diabetes Study.Glycemic Exposure Is Associated With Reduced Pulmonary Function in Type 2 Diabetes: The Fremantle Diabetes Study Diabetes Care. 2004 Mar;27(3):752-7.
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