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- March 14, 2010 |
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"Pros and cons of newer diabetes strategies - DPP-4 inhibitors and incretins"Prof. John Prins (biography)
English - 2009-05-27 - 40 minutes
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Summary :
After glucose, the incretin hormones are the most important stimulator of insulin secretion, says Prof. Prins.
The incretin effect is reduced in type 2 diabetes. Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are the two major incretin hormones. They can be increased by using oral dipeptidyl peptidase-4 (DPP-4) inhibitors which stop the breakdown of both incretins, or by injecting a GLP-1 analogue.
Modulation of the incretin system is seen as an efficacious strategy in type 2 diabetes, being complementary to other therapies and giving added efficacy. The DPP-4 inhibitors are weight neutral, and the injectable GLP-1 analogues weight reducing. There is also some suggestion of preservation/recovery of islet function with these drugs.
Prof. Prins presents efficacy and safety data on these agents, and discusses their similarities and differences in terms of effects.
Copyright © 2009 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Contributors to hyperglycaemia in T2DM
- Regulation of glucose homeostasis by incretins
- Similarities and differences between effects of DPP-4 inhibitors and GLP-1 analogues
- Efficacy and safety of these agents
Bibliographic references :
M. Nauck et al. Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes Diabetologia. Volume 29, Number 1 / January, 1986
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